Deep Neural Network-Driven Early Recognition in Cardiopulmonary Failure: A Paradigm Shift Underway in Temporary Mechanical Circulatory Support?

Authors

Monika Tukacs, Elena Giovanna Bignami, Patrick M Wieruszewski, Jacopo D'Andria Ursoleo, Justyna Swol

Published in

Artificial organs. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

The contemporary intensive care unit generates an overwhelming magnitude of high-frequency, granular physiological data. However, conventional decision-making for patients requiring temporary mechanical circulatory support (tMCS) remains tethered to reactive, threshold-driven manual adjustments, underutilizing continuous data streams and failing to optimize the complex patient-machine interaction. This review examines the integration of deep neural networks (DNNs) as a candidate strategy for advanced clinical decision support. By identifying a continuous "digital phenotype," hierarchical deep learning architectures signal a shift toward real-time trajectory recognition in tMCS. We establish a four-tier functional taxonomy-prognosticative, descriptive, predictive, and prescriptive-to categorize translational milestones from automated pump-speed optimization to closed-loop homeostatic regulation. Operational challenges are analyzed through the TEIP (Transparency, Explainability, Interpretability, and Performance) Core-Lens Framework, navigating the dynamic equilibrium between computational density and clinical explainability. We further evaluate the evolving global regulatory landscape, advocating for a foundation on verified empirical safety and rigorous clinical trial validation over absolute mathematical transparency in high-density architectures. Implementing a strategic roadmap including context-specific validation, multimodal integration, and human-centered design is quintessential to safely transform passive hardware into intelligent systems. As the field evolves, DNN technology offers a consequential opportunity to advance early cardiopulmonary failure recognition into a clinical reality.

PMID:
42855857
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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