Automation of the Azapeptide Submonomer Synthesis Method.

Authors

Tyler G Hobart, Molly E Helton, Maxwell O Bowles, Caroline Proulx

Published in

Journal of peptide science : an official publication of the European Peptide Society. Volume 32. Issue 11. Pages e70135.

Abstract

The automation of the azapeptide submonomer synthesis procedure is reported. All steps for on-resin aza-amino acid synthesis, including semicarbazone incorporation, alkylation, deprotection, and semicarbazide acylation were adapted for use on a commercially available peptide synthesizer. Key requirements for success included the use of a stable isocyanate precursor for the semicarbazone installation, the use of stable reagents in DMF, and elimination of cooling steps. The synthesis of > 30 azapeptides was accomplished using our optimized automated submonomer azapeptide synthesis procedure.

PMID:
42855876
Bibliographic data and abstract were imported from PubMed on 10 Oct 2026.

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