Xanthogranulomatous Pyelonephritis in a Horseshoe Kidney: Effective Conservative Therapy in an Immunocompromised Patient.

Authors

Mohnna Subahi, Ahmad M Albarakaty, Ahmed Almadaabgy

Published in

Cureus. Volume 18. Issue 9. Pages e116028. Epub Sep 09, 2026.

Abstract

Xanthogranulomatous pyelonephritis (XGPN) is a rare, chronic granulomatous inflammation that leads to diffuse destruction of the renal parenchyma. This destructive process may be so profound as to infiltrate surrounding tissues and viscera. Although nephrectomy remains the most common option for managing XGPN in adults, we report a case of XGPN in a horseshoe kidney of a 27-year-old woman on active immunosuppressive therapy for inflammatory bowel disease, namely ulcerative colitis. This case was successfully treated conservatively with antimicrobials, with complete resolution of the renal mass and improvement in the general condition and inflammatory markers.

PMID:
42859710
Bibliographic data and abstract were imported from PubMed on 11 Oct 2026.

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