Authors
Yi Xu, Huiyi Qiu, Chuxian Guo, Qianyun Wang, Yongjin Tang, Chongyi Huang, Jun Guo, Feifei Wang
Published in
Reviews in cardiovascular medicine. Volume 27. Issue 9. Pages 50485. Epub Sep 10, 2026.
Abstract
Fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) has emerged as a promising molecular imaging modality for visualizing fibroblast activation and extracellular matrix remodeling. In addition to its established role in oncology imaging, FAPI PET/CT is gaining recognition in the evaluation of cardiovascular disease. Emerging evidence suggests that this technique may provide molecular insights into atrial fibroblast activation and the development of a fibrotic substrate in atrial fibrillation. Meanwhile, related findings from other arrhythmias further support a potential link between myocardial fibroblast activation and electrophysiological remodeling. This review summarizes the current evidence on FAPI PET/CT imaging in atrial fibrillation, discusses related findings in other cardiovascular conditions, and highlights future directions for research in arrhythmia imaging.
PMID:
42859525
Bibliographic data and abstract were imported from PubMed on 11 Oct 2026.
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