Diagnostic variability of mental disorders in adolescence: A longitudinal study across transition boundary age.

Authors

Marta Magno, Donato Martella, Silvia Leone, Adriana Pastore, Cosmo Strozza, Elisa Caselani, Samuele Cortese, Miriam D'Addazio, Gwen Dieleman, Tomislav Franic, Suzanne Gerritsen, Athanasios Maras, Fiona McNicholas, Diane Purper-Ouakil, Paramala Santosh, Ulrike M E Schulze, Cathy Street, Swaran Singh, Sabine Tremmery, Helena Tuomainen, Larissa S van Bodegom, Dieter Wolke, Giovanni de Girolamo, MILESTONE Consortium

Published in

JCPP advances. Pages e70174. Oct 09, 2026. Epub Oct 09, 2026.

Abstract

Correct psychiatric diagnoses represent a prerequisite for the efficacy of treatment, especially during adolescence, a critical period for the onset of mental health disorders. Diagnoses can evolve over time, influenced by factors such as changes in symptoms, treatment effects, and comorbidities. The transition from Child and Adolescent Mental Health Services (CAMHS) to Adult Mental Health Services (AMHS) presents challenges due to differences in diagnostic criteria and treatment approaches. This study explores whether and how psychiatric diagnoses change during this transition, aiming to examine the prevalence and composition of primary diagnoses and identify predictors of diagnostic change.
From the MILESTONE project total sample, 770 participants aged 17-19 with available diagnoses and clinical data were included and assessed at four-time points. We categorised participants into 10 diagnostic groups based on shared clinical features. Statistical analysis included multilevel logistic regression to examine diagnosis changes, with a Sankey plot to visualise transitions.
Clinically, anxiety/trauma disorders (25.1%) were the most common at baseline, followed by depression/bipolar (21.3%) and attention deficit hyperactivity disorder (15.6%). Most diagnoses remained stable over time, with showing high stability; depression/bipolar showed moderate stability (80.7%), while schizophrenia spectrum disorders and substance use disorders exhibited nearly perfect consistency (100% and 85.7%, respectively). Multilevel logistic regression revealed that higher externalising scores (OR = 2.90; p = 0.045) was a predictor of diagnostic change, while being assessed by a psychiatrist (p = 0.037) was an index of diagnostic stability over time.
This study highlights the diagnostic stability of most psychiatric conditions during the transition from CAMHS to AMHS. Given the complexity of adolescent mental health, accurate and continuous assessment is crucial. Understanding the evolving nature of psychiatric symptoms during adolescence will improve diagnostic accuracy and inform better interventions, fostering long-term mental health outcomes.

PMID:
42859610
Bibliographic data and abstract were imported from PubMed on 11 Oct 2026.

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