COMMD family members exhibit immune-associated expression patterns following dietary selenomethionine supplementation and subsequent Bacillus cereus challenge in Pelodiscus sinensis.

Authors

Xin Zhang, Mo Yang, Xiuhong Cai, Yuyan Gong, Yuqing Liu, Shirui Yue, Zhangxuan Chen

Published in

Comparative biochemistry and physiology. Part D, Genomics & proteomics. Volume 61. Pages 102048. Oct 08, 2026. Epub Oct 08, 2026.

Abstract

The copper metabolism MURR1 domain-containing (COMMD) protein family participates in diverse cellular and immune-related processes, yet little is known about this family in reptiles. In this study, we performed a genome-wide characterization of the COMMD gene family in the Chinese soft-shelled turtle (Pelodiscus sinensis) and examined its tissue expression and transcriptional patterns following dietary selenomethionine (Se-Met) supplementation and subsequent Bacillus cereus challenge. Ten COMMD family members (COMMD1-COMMD10) were identified, all of which contained a conserved COMM domain and showed conserved evolutionary relationships with vertebrate orthologs. Most COMMD genes were highly expressed in the liver and spleen, although distinct tissue-specific patterns were observed among individual family members. After 45 days of dietary Se-Met supplementation, turtles were challenged with B. cereus, and COMMD genes exhibited heterogeneous, gene-, tissue-, and time-dependent transcriptional responses without a uniform concentration-dependent pattern. Pearson correlation analysis further revealed significant co-expression associations between several COMMD family members and representative immune-related genes, including TLR2, MyD88, TRAF6, NF-κB, TNF, and IL18. These transcriptional associations suggest potential links between COMMD family members and immune-related responses but do not establish direct regulatory relationships. This study provides a genomic and expression-level resource for future functional investigation of COMMD family members in reptilian immunity.

PMID:
42858543
Bibliographic data and abstract were imported from PubMed on 11 Oct 2026.

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