Determinants of vulnerability and onset of depression during pregnancy: Evidence from the PRESeNT cohort.

Authors

Maria Grazia Di Benedetto, Claudio Singh Solorzano, Fabio Gamba, Anna Casirati, Melissa Rosa, Elena Lanzani, Lucrezia Barbato, Francesca Pontoglio, Sharon Bonelli, Rosalba Elia, Daniela Pecis, Antonella Villa, Francesca Regispani, Lucia Reina, Barbara Sanna, Roberta De Filippis, Gabriella Fantini, Miriam Olivola, Roberta Anniverno, Marco A Riva, Annamaria Cattaneo

Published in

Brain, behavior, & immunity - health. Volume 57. Pages 101372. Epub Sep 21, 2026.

Abstract

Antenatal depression is a major public health concern, yet the factors distinguishing clinically manifest symptoms from underlying vulnerability remain poorly understood. This study examined a range of dimensions to identify determinants of antenatal depression and subclinical risk.
Two hundred thirty-one pregnant women participating in the PRESeNT cohort study have been stratified as controls (n = 71), at risk of depression during pregnancy (n = 107), or with antenatal depressive symptoms (n = 53). Assessments included psychological measures (depressive symptoms, general and pregnancy-related anxiety, stress exposure and perception, and childhood trauma), along with sociodemographic, relational, health-related, lifestyle, and obstetric variables. Group differences were tested using Kruskal-Wallis and Fisher-Freeman-Halton tests, and correlations among psychological variables were examined using Spearman's rank test. Elastic net penalized logistic regression with cross-validation was applied to identify predictors distinguishing depressed from at-risk women.
At-risk and depressed women reported higher levels of depressive symptoms, anxiety, perceived stress, and childhood trauma when compared to controls. Depressed women were more likely to be single, report poorer self-rated health, endorse pre-pregnancy substance use, and have a history of spontaneous miscarriage. In elastic net models distinguishing depressed from at-risk women, higher trait anxiety (OR = 1.11, p = 0.024) and perceived stress (OR = 1.15, p = 0.025) independently predicted depressed status.
Antenatal depression appears to be embedded within broader psychological vulnerability during pregnancy. While several relational, obstetric, lifestyle, and trauma-related characteristics were associated with group differences, psychological factors showed the strongest contribution. These findings support the implementation of integrated psychosocial screening during pregnancy to enable earlier identification and preventive care.

PMID:
42859765
Bibliographic data and abstract were imported from PubMed on 11 Oct 2026.

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