Electrical Alternans With Alternating Left Ventricular Apical Ballooning Mimicking Takotsubo Cardiomyopathy in a Patient With Extreme QT Prolongation.

Authors

Ankavipar Saprungruang, Sarin Lekchuensakul, Supaluck Kanjanauthai, Apichai Khongphatthanayothin

Published in

Journal of cardiovascular electrophysiology. Oct 11, 2026. Epub Oct 11, 2026.

Abstract

We report unique and rare findings of coupled electrical and mechanical alternans in a patient with extreme QT prolongation.
A 5-year-old girl with congenital long QT syndrome type 3 developed alternate left ventricular apical ballooning precipitated by mycoplasma pneumonia and azithromycin exposure.
During atrial pacing, electrocardiography showed beat-to-beat alternation not only in T-wave morphology but also in QRS configuration, ST segment, and QT interval. These electrical changes were tightly associated with mechanical alternans: beats with markedly prolonged QT intervals showed normal left ventricular (LV) contraction, whereas beats with shorter QT intervals and ST elevation exhibited LV apical ballooning. Treatment with mexiletine shortened the QT interval, abolished both electrical and mechanical alternans, and restored normal LV function.
Alternate LV apical ballooning mimicking Takosubo cardiomyopathy can be seen in a patient with extreme QT prolongation. These findings probably reflected a functional intraventricular conduction block due to marked spatial heterogeneity of repolarization between the LV base and apex.

PMID:
42860010
Bibliographic data and abstract were imported from PubMed on 12 Oct 2026.

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