Factors Associated with CD4+/CD8+ Ratio Normalization in People Living with HIV During Long-Term ART.

Authors

Gamze Konyalı, Fatma Merve Koçak, Ayse İnci

Published in

Infectious diseases & clinical microbiology. Volume 8. Issue 5. Pages 461-471. Epub Sep 30, 2026.

Abstract

Although HIV RNA can be suppressed with antiretroviral therapy (ART), chronic inflammation may persist in people living with HIV (PLWH). Because a low CD4⁺/CD8⁺ ratio is associated with morbidity and mortality, this study aimed to evaluate factors associated with CD4⁺/CD8⁺ ratio normalization, defined as a CD4⁺/CD8⁺ ratio ≥1.
This retrospective cohort study included PLWH aged ≥18 years who were diagnosed between 2010 and 2017 and achieved viral suppression within the first year after starting ART. Data were retrospectively obtained from a tertiary care infectious diseases clinic.
Among 217 patients who received ART for at least 5 years, 187 (86.2%) had a CD4⁺ T-cell count >500 cells/μL at year 5, and 87 (40.1%) achieved a CD4⁺/CD8⁺ ratio ≥1. In multivariable logistic regression, higher baseline CD4⁺ T-cell count and a higher baseline CD4⁺/CD8⁺ ratio were independently associated with CD4⁺/CD8⁺ ratio normalization.
Including immunological markers alongside viral suppression may better reflect treatment success. Baseline immunological status appears to be associated with long-term CD4⁺/CD8⁺ ratio normalization in PLWH receiving suppressive ART. Monitoring these markers may help inform long-term follow-up strategies.

PMID:
42861341
Bibliographic data and abstract were imported from PubMed on 12 Oct 2026.

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