Authors
Andreas K Andresen, Jacob Stampe Frølich, Leah Y Carreon, Anne Pernille Hermann, Tanja Gram Petersen, Jan Sørensen, Mikkel Ø Andersen
Published in
Brain & spine. Volume 6. Pages 107460. Epub Sep 28, 2026.
Abstract
With the on-going demographic shift towards older populations, osteoporosis is an increasing public health issue. Mortality rates after a hip fracture in the elderly have been extensively studied and reported. However, similar information has not been reported after an osteoporotic vertebral compression fracture (OVCF).
What is the mortality rate after a hospital diagnosed OVCF stratified by sex?
Using data from the Danish National Health registry, individuals with OVCFs between January 2010 and December 2023 were identified and matched 1:5 with a Control group without OVCF on age, gender, and municipality. Differences in mortality rates at intervals from 30 days to 3 years were calculated and compared for OVCF cases and Controls. A similar analysis was used to explore sex differences for individuals with OVCF.
A total of 37,948 patients with OVCF, 12,693 males and 25,255 females were matched with 63,243 and 123,477 Controls, respectively. Individuals with OVCF had statistically significantly higher mortality rates than Controls. Mortality among individuals with OVCF was statistically significantly higher for males than for females.
A significantly higher mortality rate among patients with OVCFs compared to non-fracture controls was seen. OVCFs in males were associated with an almost two-fold higher risk of all-cause mortality compared to females. Increased awareness of osteoporosis in the male population and related morbidity should be further addressed in research and clinical practice.
PMID:
42861261
Bibliographic data and abstract were imported from PubMed on 12 Oct 2026.
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