Fidelity during bacterial protein synthesis.

Authors

Cierra Wilson, Zhihui Lyu, Jiqiang Ling

Published in

Microbiology and molecular biology reviews : MMBR. Pages e0033725. Oct 12, 2026. Epub Oct 12, 2026.

Abstract

SUMMARYTranslational fidelity is maintained throughout evolution and ensures the accurate flow of genetic information from mRNA to protein. Both aminoacyl-tRNA synthetases and ribosomes use substrate selection and proofreading to lower translational errors. However, genetic mutations and environmental changes frequently alter translational fidelity. Recent technological advances have enabled sensitive detection of translational errors and high-throughput screening of conditions that alter translational fidelity. With a focus on Escherichia coli and Salmonella enterica, this article reviews the methods used to quantitate translational errors in vivo, the impact of various stresses and metabolic changes on translational fidelity, and the effects of altered translational fidelity on evolution, stress adaptation, and bacteria-host interactions.

PMID:
42861974
Bibliographic data and abstract were imported from PubMed on 12 Oct 2026.

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