Increasing Detection of Early-Onset Rectal Neuroendocrine Neoplasms in the Era of Earlier Colorectal Cancer Screening.

Authors

Maher Al Khaldi, Zubair Bayat, Noam Kahana, Michal Perets, Sameh Hany Emile

Published in

The American surgeon. Pages 31348261495992. Oct 12, 2026. Epub Oct 12, 2026.

Abstract

BackgroundThis study aimed to evaluate contemporary national trends in the presentation, management, and outcomes of early-onset rectal neuroendocrine neoplasms (EORNETs).MethodsA retrospective cohort analysis of patients <50 years who underwent surgery for rectal neuroendocrine neoplasms was performed using the National Cancer Database (NCDB) (2004-2023). Patients undergoing surgery were categorized as local tumor excision or radical resection. Five-year overall survival (OS) was estimated using Kaplan-Meier analysis, and multivariable Cox proportional hazards analysis was used to identify factors associated with OS. A sensitivity analysis was also performed in the well-differentiated neuroendocrine tumor subgroup.Results7285 patients were included; 6638 (91.1%) underwent local excision and 647 (8.9%) radical resection. The annual number of surgically treated cases increased from 234 in 2004 to 778 in 2023. 83.0% of tumors with known grade were low grade, and 90.6% of tumors with known clinical stage were stage I. Radical resection was associated with larger tumors, higher grade, more advanced stage, lymphovascular invasion, and liver metastases (all P < .001). Five-year OS was higher after local excision than radical resection (97.5% vs 85.7%, P < .001). In the full multivariable model, radical resection was associated with worse OS (HR 3.43, 95% CI 1.60-7.36; P = .002); however, this association was no longer statistically significant in the well-differentiated tumor subgroup (HR 2.52, 95% CI 0.97-6.54; P = .057).ConclusionsThe number of surgically treated EORNET cases substantially increased over time. Local excision was the predominant treatment. These findings are compatible with increased detection of indolent lesions through greater endoscopic evaluation.

PMID:
42862093
Bibliographic data and abstract were imported from PubMed on 12 Oct 2026.

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