Copper-catalyzed cis-addition of isocyanides with internal alkynes.

Authors

Daiying Lv, Dianpeng Chen, Jia Wang, Jianming Li, Yingying Shan

Published in

Chemical communications (Cambridge, England). Oct 12, 2026. Epub Oct 12, 2026.

Abstract

A novel copper-catalyzed cis-addition of isocyanides to internal alkynes is reported. This transformation enables the selective construction of two distinct classes of synthetically valuable N-heterocycles, 2-amino-5-cyanopyrroles and 5-iminopyrrolones, in high to excellent yields. The protocol exhibits a remarkably broad substrate scope, excellent functional-group tolerance, and operational simplicity, thus providing a versatile and practical synthetic platform for the rapid assembly of these privileged heterocyclic scaffolds.

PMID:
42861845
Bibliographic data and abstract were imported from PubMed on 12 Oct 2026.

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