Interfacial microenvironments enable abiotic ribonucleoside formation in micro- and nanoscale compartments.

Authors

Qiang Liu, Xia Zhao, Jae Kyoo Lee, Richard N Zare

Published in

Proceedings of the National Academy of Sciences of the United States of America. Volume 123. Issue 42. Pages e2624803123. Oct 20, 2026. Epub Oct 12, 2026.

Abstract

The abiotic emergence of ribonucleosides remains a central challenge in origin-of-life research because ribonucleosides form inefficiently and are often unstable under prebiotically plausible conditions. Here we show that interfacial microenvironments within aqueous micro- and nanoscale compartments containing D-ribose, phosphoric acid, and nucleobases promote ribonucleoside formation by creating reaction-permissive physicochemical conditions independent of the specific compartment type. Across a diverse range of compartmentalized systems, including gas-oil-water micro/nanobubbles, gas-water micro/nanobubbles, microscale lipid-bilayer vesicles, and oil-water emulsion systems, ribonucleosides form abiotically in the absence of enzymatic catalysis. Under selected interfacial conditions, multiple ribonucleosides, including cytidine, are generated without added catalysts. Comparison among these systems reveals that interfacial architecture and coupled physicochemical properties strongly influence both reaction efficiency and product stability. CO₂-based micro/nanobubbles support sustained cytidine accumulation, highlighting the importance of coupled gas-liquid and liquid-liquid interfaces. Ribonucleoside synthesis also depends on compartment size, whereas variations in oil content within micro/nanobubbles selectively modulate inosine formation, underscoring the sensitivity of nucleoside chemistry to interfacial properties. These findings identify interfacial microenvironments within micro- and nanoscale compartments as a general physical framework for ribonucleoside emergence and suggest that ubiquitous compartmentalized interfaces on early Earth could have provided robust settings for prebiotic ribonucleoside chemistry.

PMID:
42863069
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.