Helical Folding of Abiotic Chiral Poly(phosphodiester)s.

Authors

Ranajit Barman, Brice Kauffmann, Jean-François Lutz, Victor Maurizot

Published in

Chemistry (Weinheim an der Bergstrasse, Germany). Volume 32. Issue 34. Pages e71189. Sep 11, 2026. Epub May 28, 2026.

Abstract

Functions of biomolecules are intimately linked to their structures which result from the folding of a linear sequence of building blocks, amino-acids for proteins and nucleotides for DNA. In the quest to achieve functions with similar efficiency and selectivity that of biomolecules, several synthetic mimics of secondary structures of proteins have been developed but, on the other hand, only scares examples of de novo design of DNA mimics are available. Most of described DNA inspired molecular systems are based on modifications of either the sugar/phosphate backbone or nucleobases. Here are presented the design, the synthesis and the structural characterization of a new class of synthetic phosphodiester oligomers, composed of an aromatic chiral building block, that fold into single helical architectures. Folding pattern diverge from its natural counterpart (DNA) but through intramolecular H-bonds and aromatic stacking these oligomers show similar cooperative temperature dependence stability.

PMID:
42210037
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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