Modeling the Exposome in Murine Cardiovascular Disease.

Authors

Bibi Alika Sulaman, Jing Zhu, Ting Xiong, Taylor E Ireland, Jeffrey Downey, Filip K Swirski, Clinton S Robbins, Nicholas J Leeper, Wolfram C Poller, Cameron S McAlpine

Published in

JACC. Basic to translational science. Volume 11. Issue 10. Pages 101690. Sep 11, 2026. Epub Sep 11, 2026.

Abstract

Our exposome, encompassing our environmental and lifestyle exposures across the life span, is a critical determinant of cardiovascular health. Clinical and epidemiological data demonstrate that sleep, stress, exercise, smoking, viral respiratory infections, and environmental pollution each modulate cardiovascular disease (CVD) risk, yet the pathobiological mechanisms underlying these associations remain poorly understood. Fundamental research into how the exposome and the physiological responses to it shape cardiovascular pathophysiology holds significant promise for expanding biologic understanding and identifying novel mechanisms with therapeutic potential. Essential to such investigations are murine CVD models subjected to translatable, precise, and tractable exposomic modification. Here, we review the experimental approaches for manipulating these select environmental and lifestyle factors in mice and highlight the emerging evidence for causal holistic mechanisms linking the exposome to experimental CVD.

PMID:
42727218
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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