Thiol reactivity: lost in the crowd?

Authors

Eduardo Fuentes-Lemus, Michael J Davies

Published in

Trends in biochemical sciences. Oct 12, 2026. Epub Oct 12, 2026.

Abstract

Predictions of cysteine reactivity rely heavily on acidity (pK_a) data from dilute solutions. However, the intracellular milieu is crowded and dynamic, with substrates, cofactors, and metabolites that modulate reactivity, thereby affecting cell signaling and metabolic adaptation. This forum argues that Cys pK_a values are necessary but insufficient, proposing an integrated, microenvironment-dependent framework.

PMID:
42864242
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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