Hitting KRAS G12D without the gut punch: Can immunotherapy make it last?

Authors

Dae Won Kim, Ignacio Garrido-Laguna

Published in

Cancer cell. Volume 44. Issue 10. Pages 1921-1923. Oct 12, 2026.

Abstract

In this issue of Cancer Cell, Shi et al. report encouraging early-phase results combining HRS-4642, an allele-specific KRAS G12D inhibitor, with the PD-L1 inhibitor adebrelimab in previously treated metastatic pancreatic cancer. The intravenous combination was safe and well tolerated, notably sparing patients the gastrointestinal toxicity common to oral KRAS inhibitors, and achieved a promising 43% response rate at the recommended dose.

PMID:
42863460
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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