Microbial cues for a stem-like lymphoid niche.

Authors

Ming Kuang

Published in

Cancer cell. Volume 44. Issue 10. Pages 1916-1917. Oct 12, 2026.

Abstract

While tertiary lymphoid structures (TLSs) broadly correlate with immunotherapy efficacy, their functional heterogeneity can translate into divergent clinical outcomes. In this issue of Cancer Cell, Hu et al. uncover a microbiota-orchestrated stem-like lymphoid niche in which CD70⁺ ILC2s sustain progenitor exhausted T cells, and their findings redefine the functional organization underlying TLS-associated antitumor immunity.

PMID:
42863459
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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