Cytotoxicity and α-Amylase Inhibitory Activities of Limonoids From the Leaves of Azadirachta indica.

Authors

Ying Yang, Yu-Xin Yan, Ming-Hua Qiu

Published in

Chemistry & biodiversity. Volume 23. Issue 10. Pages e71835.

Abstract

Three new limonoids, azadiraindins H-J (1-3), together with three known analogues, were isolated from the leaves of Azadirachta indica. The structures of these compounds were elucidated by comprehensive spectroscopic analysis, including IR, MS, HR-ESI-MS, 1D NMR, and 2D NMR. In addition, all compounds exhibited cytotoxic activities in vitro against HL-60, A-549, MCF-7, and SW480 cell lines, with IC₅₀ values ranging from 7.51 to 21.97 µM. Notably, compound 2 demonstrated significant cytotoxicity.

PMID:
42864973
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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