The Effect of Prophylactic Protection of Inferior Parathyroid Gland Vein Blood Supply on Reducing Postoperative Hypoparathyroidism.

Authors

Liping Liu, Dehao Yu, Shichao Li, Lei Liu, Xinhua Yang, Haoxi Liu

Published in

Cancer medicine. Volume 15. Issue 10. Pages e72360.

Abstract

The objective of this study was to verify that a strategy involving prophylactic exposure of the inferior parathyroid glands and preservation of their venous blood flow-achieved through early identification and protection of their venous drainage-can enhance the success rate of maintaining glandular perfusion and effectively reduce the incidence of postoperative hypoparathyroidism.
This study included 600 patients who underwent total thyroidectomy with concomitant bilateral central neck dissection between November 2019 and December 2025. Patients were divided into two groups based on the surgical technique: Group A (n = 244), in which a prophylactic approach was used to protect the venous drainage of the inferior parathyroid glands, and Group B (n = 356), which underwent conventional in situ preservation of the inferior parathyroid glands. A comparison was made between the two groups regarding both the percentage of inferior parathyroid glands successfully preserved in situ and the incidence of postoperative hypoparathyroidism.
The rate of visualization of inferior parathyroid glands with optimal blood supply was significantly higher in Group A than in Group B (p < 0.001). Postoperation parathyroid hormone level in Group A was significantly higher than that in Group B (25.15 [19.39, 33.58] pg/mL vs. 19.12 [9.82, 28.85] pg/mL, p < 0.001). In Group A, the rates of postoperative hypoparathyroidism-encompassing both transient and permanent forms-were significantly lower than those in Group B (p < 0.001).
The method of prophylactically exposing the inferior parathyroid glands and preserving their venous system-termed prophylactic preservation of inferior parathyroid venous blood flow-is achieved through early identification and protection of their venous drainage. This approach enhances the success rate of maintaining glandular blood supply and effectively reduces the incidence of postoperative hypoparathyroidism.

PMID:
42864760
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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