Visible-light driven macrocyclization of peptides: from a vinyl to an α-selenoketone motif.

Authors

Mateusz Waliczek, Zuzanna Słomiana, Klaudia Faba, Martyna Strączek, Piotr Stefanowicz

Published in

Organic & biomolecular chemistry. Oct 13, 2026. Epub Oct 13, 2026.

Abstract

We report a visible-light-driven, chemoselective macrocyclization of peptides that converts linear vinyl precursors into cyclic products bearing an α-selenoketone motif. The transformation proceeds in aqueous medium under mild conditions using a substoichiometric photocatalyst and blue LED irradiation, delivering high yields (>90%). The method is operationally simple, green, and broadly applicable to peptide macrocyclization.

PMID:
42865116
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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