Primary pulmonary NUT carcinoma: pathological features, clinical diagnosis, treatment, and prognosis - An extended review.

Authors

Shan Wu, Miao Zhang, Hui Wang

Published in

Oncology reviews. Volume 20. Pages 1967215. Epub Sep 28, 2026.

Abstract

NUT carcinoma is a rare and aggressive lung tumor driven by NUTM1 gene rearrangements. It accounts for less than 1% of all lung cancers, with fewer than 100 cases reported worldwide. The disease is often misdiagnosed due to non-specific symptoms and histological overlap with other tumors. This review provides an updated overview of its pathological features, clinical presentation, diagnosis, treatment, and prognosis, aiming to serve as a practical reference for clinicians and pathologists.

PMID:
42865603
Bibliographic data and abstract were imported from PubMed on 13 Oct 2026.

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