Different variants, different cellular outcomes: Balanced KIF1A activity shapes synapse development.

Authors

Shinsuke Niwa

Published in

The Journal of cell biology. Volume 225. Issue 11. Nov 02, 2026. Epub Oct 13, 2026.

Abstract

In this issue, Aiken et al. (https://doi.org/10.1083/jcb.202601034) show that pathogenic KIF1A variants induce distinct effects on axonal transport, cargo distribution, and neuronal development. Their findings suggest that balanced KIF1A activity is required for proper synaptic development and function.

PMID:
42867410
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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