Authors
Alex Waldherr, Gesa L Freimann, Andrei N Lupas
Published in
Protein science : a publication of the Protein Society. Volume 35. Issue 11. Pages e70809.
Abstract
Non-standard amino acids (ncAAs) together with synthetic additions (like caps and linkers) are of wide interest for protein design and pharmaceutical optimization, as they can improve physicochemical properties and possibly reshape protein structure. Their inclusion in experimental structures has not been explored systematically. It remains elusive which components are those most impactful for protein design. We therefore collected all non-standard components present in the Protein Data Bank (PDB) into MONDE·T: A database of 1,210 unique ncAAs and 724 other synthetic components present in 23,149 PDB structures with a corresponding webserver. Analyses can focus on a single component or a single structure, illustrated here by example applications. MONDE·T allows for download of the data, visualization of a structure, identification of unusual backbone angles, and comparison of chemical similarities. The webserver is hosted at the Max Planck Institute Tübingen, accessible online via https://mondet.tuebingen.mpg.de/. MONDE·T is freely available under the Creative Commons 4.0 License.
PMID:
42867160
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 5
- Comments 0