Beyond independent roles: spatiotemporal coupling between viral fusion proteins and viroporins in viral replication and host inflammation.

Authors

Jiaqi Li, Yuan Sun, Hua-Ji Qiu, Su Li

Published in

Journal of virology. Pages e0101326. Oct 13, 2026. Epub Oct 13, 2026.

Abstract

Membrane fusion and permeabilization are key membrane remodeling processes hijacked by viruses. Although fusion proteins and viroporins have long been characterized as discrete functional modules, emerging evidence supports the spatiotemporal coordination through shared regulation of ion flux, pH homeostasis, membrane tension, organelle stress, and vesicular trafficking during viral infections. These synchronized membrane events synergistically shape viral replication and host immune responses. This review establishes a fusion-ion-inflammation axis to guide mechanistic exploration and antiviral drug development.

PMID:
42867235
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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