Functional properties of globularia alypum methanolic extract: towards natural antimicrobial and anti-inflammatory agents.

Authors

Baya Mhamdi, Rim Essid, Chedia Aouadhi, Sriti Jazia

Published in

Natural product research. Pages 1-8. Oct 13, 2026. Epub Oct 13, 2026.

Abstract

The present study investigated the phytochemical composition and the antioxidant, antibacterial, and anti-inflammatory activities of the methanolic leaf extract of Globularia alypum. RP-HPLC analysis identified four phenolic acids and four flavonoids, with rutin as the predominant compound (38.02 µg/g DW). The extract exhibited notable antioxidant activity, with a DPPH IC₅₀ value of 50 µg/mL. Antibacterial assays demonstrated inhibitory activity against all six tested bacterial strains, with the greatest susceptibility observed for Escherichia coli and Staphylococcus aureus, showing inhibition zones of 17 and 15 mm, respectively, and MIC values of 12.5 mg/mL. In addition, the extract reduced nitric oxide production in LPS-stimulated RAW 264.7 macrophages (IC₅₀ = 1000 µg/mL) with no pronounced cytotoxicity at the tested concentrations, indicating detectable NO-inhibitory activity under the experimental conditions. These findings highlight G. alypum leaves as a valuable source of bioactive phenolic compounds with promising antioxidant, antibacterial, and anti-inflammatory properties.

PMID:
42866946
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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