Authors
JodiRae DeDreu, Caitlin M Logan, Mary J Mattapallil, Rachel R Caspi, Mary Ann Stepp, A Sue Menko
Published in
The American journal of pathology. Oct 13, 2026. Epub Oct 13, 2026.
Abstract
In Experimental Autoimmune Uveitis (EAU) mice, immune cells with an immunoregulatory phenotype are recruited to the surface of the avascular lens, traveling across ciliary zonule fibrils from the vasculature-rich ciliary body. It was also discovered that the lens epithelium harbors a population of tissue resident immune cells, a cell type associated with inducing immune responses in response to danger signals in their environment, including recruitment of immune cells that function in immune surveillance and resolution of inflammation. In this study, we examine the phenotype and localization of Lens Resident Immune Cells (LR-IC), quantify their presence in adult mouse lenses and investigate whether there is a relationship between recruitment of Lens Capsule Associated Immune Cells (LCA-ICs) and the activation of LR-ICs in EAU. This study focused on the time-period between induction of uveitis and the height of inflammation in the eyes of EAU mice. High-resolution confocal microscopy was performed on mouse eyes immunolabeled for molecules that detect activated resident immune cells or LCA-ICs. Quantification revealed that few LCA-ICs are recruited to the lens surface prior to the height of EAU inflammation, with the correlation between recruitment of immune cells to the lens capsule surface and the activation of LR-ICs occurring at the height of inflammation. These findings suggest LR-IC activation may contribute to regulation of inflammatory responses in the eye.
PMID:
42869285
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 10
- Comments 0