Authors
Jiao Fu, Wen-Hui Men, Shi-Yi Shi, Meng Yuan, Hui-Qin Chen, Wen-Li Mei, Zhi-Yong Guo, Xue-Qing Zhang
Published in
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. Volume 51. Issue 18. Pages 5282-5288.
Abstract
Six secondary metabolites were isolated from the rice fermentation products of the endophytic fungus Penicillium polonicum from Emmenopterys henryi by silica gel column chromatography, gel column chromatography, and semi-preparative high-performance liquid chromatography(HPLC). Their structures were elucidated by NMR, mass spectrometry, and other spectroscopic methods in combination with literature data. The compounds were identified as penicilazine A(1), penicilazine B(2), penicilazone C(3), chermesinone B(4), chaetoglobosin G(5), and communesin D(6). Compounds 1 and 2 are diketopiperazine alkaloids. Among them, compound 1 was obtained from nature for the first time, and compound 2 was identified as a new compound. Compound 3 was identified as a new azaphilone-type compound. Antibacterial activity assays showed that compound 1 exhibited moderate antibacterial activity against Vibrio alginolyticus, Staphylococcus aureus, and Erwinia carotovora with MIC values of 12.5, 12.5, and 25 μg·mL~(-1), respectively. Compound 2 displayed antibacterial activity against V. anguillarum and V. alginolyticus, with MIC values of 25 μg·mL~(-1) for both strains.
PMID:
42869834
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.
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