[Research progress on structural characterization and pharmacological mechanisms of supramolecular aggregates in traditional Chinese medicine decoctions].

Authors

Shuang Liu, Hong-Jing Dong, Chuan-Zhi Kang, Yu-Zhang Mi, Xiao Wang

Published in

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. Volume 51. Issue 17. Pages 4886-4894.

Abstract

The investigations on pharmacodynamic material basis of traditional Chinese medicine have focused primarily on free compounds, while overlooking the complex interactions among active constituents. In recent years, it has been revealed that active constituents can self-assemble into supramolecular aggregates through non-covalent interactions during the decoction process, providing a new perspective for elucidating the pharmacodynamic material basis of traditional Chinese medicine. This study systematically reviewed the separation and purification methods and structural characterization techniques for supramolecular aggregates, explored their self-assembly mechanisms in depth, and summarized the pharmacological mechanisms. Finally, it examined the limitations of existing studies in terms of separation technologies, self-assembly mechanisms and in vivo metabolism, and proposed future research directions,with the aim of providing a reference for further in-depth research, development and utilization of supramolecular aggregates in traditional Chinese medicine.

PMID:
42869795
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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