Authors
Negar Narimisa, Tahereh Navidifar, Tuqa T Hameed, Roghayeh Mohammadzadeh, Faranak Abdoli, Mahsa Ghamari, Delaram Nourollahi, Fatemeh Ansari, Arefeh Ansari, Narjess Bostanghadiri
Published in
MicrobiologyOpen. Volume 15. Issue 5. Pages e70434.
Abstract
Vancomycin-resistant enterococci (VRE) are an increasing public health concern. However, the contribution of environmental reservoirs to the global epidemiology of vancomycin resistance remains unclear. This meta-analysis estimated the prevalence of Vancomycin-resistant Enterococcus faecalis (VREfs) and vancomycin-resistant Enterococcus faecium (VREfm) from clinical and environmental specimens worldwide. We conducted a systematic literature search in PubMed, Web of Science, Embase, and Scopus up to 26 April 2025. Statistical analysis was performed using the meta and metaphor packages in R, and heterogeneity was evaluated using I2. We assessed potential publication bias using Egger's test. A total of 349 eligible studies were included. The pooled prevalence of VREfm was 25%, and VREfs was 5%. The prevalence of both VREfs and VREfm increased significantly during the last two decades. The highest prevalence of VREfm and VREfs was found in rectal swabs (76%), hospital environmental samples (74%), environmental water (26%), and animal stool (40%). By integrating clinical and environmental data, the present study highlights the possible role of non-clinical reservoirs in the persistence and dissemination of VRE. Our results support the One Health approach for VRE surveillance and emphasize the need for environmental surveillance in infection prevention and antimicrobial resistance control strategies.
PMID:
42870516
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 18
- Comments 0