Authors
Ruichuan Duan, Xinru Xiao, Yewei Jia, Shuqi Ren, Yucheng Sun, Guijun Wan, Fajun Chen
Published in
Pest management science. Oct 14, 2026. Epub Oct 14, 2026.
Abstract
Elevated atmospheric carbon dioxide (eCO2) exacerbates feeding damage of the destructive rice pest brown planthopper (Nilaparvata lugens). Neuropeptide F (NPF) and short Neuropeptide F (sNPF) are core regulators of insect feeding and metabolism, yet their functions in mediating N. lugens responses to eCO2 remain unclear. This study aimed to elucidate the roles of NPF and sNPF in modulating the feeding behavior, lipid metabolism and oxidative balance of N. lugens under eCO2.
NPF/sNPF knockdown prolonged N. lugens feeding duration, with more prominent effects under eCO2 than ambient CO2. Silencing the two genes enriched differential expression genes in 'fat digestion and absorption' pathways, and it significantly elevated triglyceride and free fatty acid contents, reduced the ratio of polyunsaturated to saturated fatty acids, and triggered higher reactive oxygen species and malondialdehyde levels with weakened antioxidant capacity, ultimately increasing pest mortality. Dual gene knockdown exerted stronger impacts than single knockdown, and all phenotypic changes were amplified under eCO2.
NPF and sNPF coordinately regulate the feeding, lipid homeostasis and oxidative balance of N. lugens under eCO2. The close correlation of their regulatory effects with lipid metabolism and oxidative stress clarifies the molecular mechanism of pest climate adaptation. This work advances climate-related pest resistance research and provides promising molecular targets for brown planthopper biocontrol. © 2026 Society of Chemical Industry.
PMID:
42870707
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.
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