Approaches in Opioid Pharmacology: Toward Safer Pain Management.

Authors

Rini Singhal, Chhaya Chauhan

Published in

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Volume 40. Issue 20. Pages e72379. Oct 31, 2026.

Abstract

Opioids are crucial for pain management, but the traditional mu-opioid receptor agonists are associated with considerable risk, such as addiction, overdose, and serious side effects such as respiratory depression. This review aims to emphasize the recent developments in the development of safer opioids, including approaches such as mixed agonists at MOR, KOR, and DOR, biased agonists at MOR, KOR, and DOR, and allosteric modulation. Other approaches, such as peripherally acting opioids and agonists at MOR splice variants, are also discussed as safer options for pain management without the risk of central side effects.

PMID:
42870521
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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