Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine.

Authors

Gyuzel Y Mitronova, Vladimir N Belov, Constanze Schmidt, Stephan E Lehnart

Published in

ChemMedChem. Volume 21. Issue 19. Pages e70506. Oct 14, 2026.

Abstract

This review provides an overview of recent advances in the development of multitarget drugs (MTDs) for cardiac diseases, with a particular focus on emerging molecular scaffolds and their pharmacological properties. We discuss the fundamental principles of cardiac polypharmacology and multitarget drug design, highlighting key compound classes, such as 1,4-benzothiazepines, 1,4-dihydropyridines (DHPs), and polyphenol derivatives. Particular emphasis is placed on the relationship between the structural features and the pharmacological activity, efficacy, and therapeutic potential of these compounds.

PMID:
42870355
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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