Authors
Hiroaki Kitaoka, Toru Kubo, Makio Torigoe, Yuika Ikeda, Kanako Shimoura, Shintaro Suo, Ryohei Takeda, Yuichiro Maekawa
Published in
Future cardiology. Pages 1-12. Oct 13, 2026. Epub Oct 13, 2026.
Abstract
To describe the burden of hypertrophic cardiomyopathy (HCM) using patient-reported outcome tools and a study-specific questionnaire.
This two-phase, cross-sectional, non-interventional, observational study (qualitative [previous] and quantitative [current]) included adults with HCM and New York Heart Association functional classification 2/3 recruited from healthcare facilities across Japan. The International Physical Activity Questionnaire (IPAQ), Kansas City Cardiomyopathy Questionnaire (KCCQ), Hypertrophic Cardiomyopathy Symptom Questionnaire (HCMSQ), and Hospital Anxiety and Depression Scale (HADS) were used alongside a questionnaire developed using the qualitative findings.
The analysis included 120 patients (mean age, 59.1 ± 16.3 years; 55.5% [66/120] male), 60 each with non-obstructive and obstructive HCM. Patients with (vs. without) lifestyle changes had lower median IPAQ score (495.0 [363.0-1803.5] vs. 990.0 [369.4-2295.0], p = 0.159) and KCCQ - Clinical Summary Score (81.3 [65.6-90.7] vs. 92.0 [81.4-97.9], p < 0.001), and higher HADS-Depression (5.0 [3.0-8.0] vs. 2.0 [1.0-6.0], p = 0.001) and HCMSQ-shortness of breath (5.0 [2.0-6.0] vs. 3.0 [0.0-4.5], p < 0.001) scores. Most patients (83.9%) noticed HCM symptoms, and some patients attributed symptoms to causes other than HCM. Most patients (89.0%) told others about their HCM. Primary care physicians were the main information source (99.2%).
In this quantitative analysis, HCM affected patients' lifestyles and physical activity.
NCT06181617 (ClinicalTrials.gov).
PMID:
42870498
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 17
- Comments 0