A review of protective effects of Withania somnifera and its bioactive component withaferin A in organ ischemia-reperfusion injury.

Authors

Jiabing Wang, Nan Jin, Shihao Li, Binhui Wang, Xi Chen

Published in

Frontiers in pharmacology. Volume 17. Pages 1961846. Epub Sep 29, 2026.

Abstract

Withania somnifera (WS) is an Ayurvedic botanical which has been extensively studied for thousands of years. Withanolides are the main pharmacologically active ingredients isolated from WS and withaferin A (WA) is the most extensively studied and therapeutically effective withanolide compound. WS and WA have anti-ischemia-reperfusion injury effects. To summarize and investigate the protective roles of WS and WA and their underlying mechanisms in organ ischemia-reperfusion injury, a comprehensive literature search was conducted using databases including PubMed and Web of Science. Relevant in vitro and preclinical regarding WS and WA in the treatment of organ ischemia-reperfusion injury. By analyzing the existing research advances, we found that the anti-organ ischemia-reperfusion injury effects of WS and WA, primarily mediated through anti-apoptosis, anti-oxidative stress, anti-inflammatory, anti-mitochondrial dysfunctions, induction of neuronal regeneration and inhibition of migration. This review systematically summarizes the different roles and mechanisms of WS and WA in organ ischemia-reperfusion injury and provides a basis for future therapeutic investigation of organ ischemia/reperfusion injury.

PMID:
42871614
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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