Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction.

Authors

Vibhudutta Awasthi, Tarun W Dasari, Kenichi A Tanaka

Published in

ACS pharmacology & translational science. Volume 9. Issue 10. Pages 3000-3004. Oct 09, 2026. Epub Sep 17, 2026.

Abstract

Dozens of agents that limit reperfusion injury preclinically have failed clinically. These failures are architectural, not biological: the right biology reaches the wrong place, as the wrong molecule, at the wrong time, judged by the wrong end point. We recast each as a design constraint and specify a staged regimen anchored at first medical contact.

PMID:
42871611
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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