Suboptimal Response to Eculizumab in Renal-Limited Thrombotic Microangiopathy Associated With Malignant Hypertension and Monoclonal Gammopathy: A Case Report.

Authors

Wenjuan Lei, Tianli Shi, Man Xu, Jun Zhou

Published in

Clinical case reports. Volume 14. Issue 10. Pages e73712. Epub Oct 12, 2026.

Abstract

Renal-limited thrombotic microangiopathy (TMA) is clinically milder but etiologically complex and is often underdiagnosed. This case presents as complement-mediated TMA with malignant hypertension and monoclonal gammopathy but showed suboptimal response to eculizumab treatment, suggesting heterogeneity in both etiology and treatment outcomes.

PMID:
42871604
Bibliographic data and abstract were imported from PubMed on 14 Oct 2026.

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