Association of Neutrophil-To-Lymphocyte Ratio and Atherogenic Index of Plasma With Angiographically Confirmed Coronary Artery Disease.

Authors

Xuexue Yang, Xiaofang Xiong, Dongsheng Li

Published in

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. Volume 32. Pages 10760296261497036. Epub Oct 14, 2026.

Abstract

BackgroundThe neutrophil-to-lymphocyte ratio (NLR) and atherogenic index of plasma (AIP) have been associated with coronary artery disease (CAD). We investigated their associations with angiographically confirmed CAD and lesion severity.MethodsThis retrospective study included 2,933 patients undergoing coronary angiography for suspected CAD at Wuhan Third Hospital. CAD was defined as ≥50% luminal stenosis in at least one major coronary artery or branch. Lesion severity was assessed using the Gensini score. Multivariable logistic regression and receiver operating characteristic analyses were performed.ResultsAmong 2,933 patients, 1,615 had CAD and 1,318 had no significant stenosis. NLR and AIP were higher in patients with CAD and increased across Gensini score categories (all P<0.05). After adjustment, AIP remained independently associated with CAD (OR=1.557, P=0.042), whereas NLR did not (OR=1.019, P=0.581). AIP alone showed limited discrimination (AUC=0.537). A multivariable model including age, blood pressure, fasting blood glucose, and AIP showed an AUC of 0.779. Adding AIP did not significantly improve AUC (DeLong P=0.153) or NRI (0.071, P=0.106), although IDI improvement was significant (0.002, P<0.05).ConclusionsIn patients undergoing coronary angiography for suspected CAD, NLR and AIP were associated with CAD and angiographic disease burden. AIP remained independently associated with CAD, whereas NLR did not. However, AIP showed limited discrimination and no clear incremental improvement beyond conventional variables. These findings do not support population screening or routine clinical implementation.

PMID:
42874061
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.