Chemoselective Electrochemical Synthesis of 3-Hydroxyisoindolinones from Phthalimide Imines.

Authors

Xi Zhang, Yicai Li, Qiaohong Xu, Zenghui Ye, Wei-Yuan Ma, Jian-Xing Xu, Fengzhi Zhang

Published in

The Journal of organic chemistry. Oct 15, 2026. Epub Oct 15, 2026.

Abstract

We report an electrochemical method for the radical-radical coupling of alkyl iodides with phthalimide imines under mild conditions. This operationally simple electro-reductive procedure enables selective reduction of carbonyl groups, offering an efficient route to access functionalized 3-hydroxyisoindolinones in moderate-to-excellent yields. Notably, the highly functionalized 3-hydroxyisoindolinones have shown promising bioactivity in preliminary assessments, pointing to the significant potential of this chemical scaffold for anticancer cell applications. A comparative analysis has demonstrated that the hydrazone moiety within the product structure plays an indispensable role in conferring bioactivity.

PMID:
42874025
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.