Screening strategies for the early detection of non-cardia gastric cancer in low- to moderate-prevalence regions: Asia-Pacific gastroesophageal cancer congress consensus 2026.

Authors

Ayaka Takasu, Fumiaki Ishibashi, Rapat Pittayanon, Hon Chi Yip, James Weiquan Li, Munkhsaruul Bayaraa, Hyunsoo Chung, Do Hoon Kim, Kamin Harinwan, Quang Dinh Le, Adolfo Parra-Blanco, Paulo Kassab, Vincenzo Giorgio Mirante, José Murillo-Rodriguez, Regina Rie Imada, Renata Nobre Moura, Sabina Beg, Pedro Genaro Delgado-Guillena, Marta Rodriguez-Carrasco, Seung-Hun Chon, Chul S Hyun, Grigorios Christodoulidis, Vo Duy Long, Zili Xiao, Sergey Kashin, Roman Kuvaev, Ian Yu-Hong Wong, Robert Bechara, Mitsuru Esaki, Waku Hatta, Motohiko Kato, Seiichiro Abe, Sho Suzuki, Kohei Takizawa, Joo Ha Hwang, Wai Keung Leung, Duc Trong Quach, Matsuda Satoru, Han-Kwang Yang, Takuji Gotoda

Published in

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. Oct 14, 2026. Epub Oct 14, 2026.

Abstract

Gastric cancer (GC) remains a major global health burden, and early detection is essential for improving patient outcomes. Although GC screening has been widely implemented in East Asian countries with a high disease burden, the optimal screening strategy for low- to moderate-prevalence regions remains unclear. To address this gap, the Asia Pacific Gastroesophageal Cancer Congress (APGCC) convened an international consensus meeting to develop evidence-based recommendations for improving the detection of non-cardia gastric cancer (NCGC).
The APGCC working group developed 11 clinical questions (CQs) addressing GC screening, with a particular focus on NCGC. For each CQ, assigned authors conducted literature reviews using PubMed and prepared evidence summaries and draft recommendations. Consensus was achieved through a two-round modified Delphi process involving 37 international voting members.
The consensus recommendations addressed population-based screening, screening modalities, identification of high-risk individuals, quality indicators for esophagogastroduodenoscopy (EGD), image-enhanced endoscopy, and artificial intelligence-assisted endoscopy. Population-based endoscopic screening is not recommended in low- to moderate-prevalence regions because of insufficient evidence. However, if screening is performed, EGD is preferred over upper gastrointestinal series for the detection of early NCGC in asymptomatic individuals. The recommendations also emphasize the importance of high-quality endoscopic examinations, risk-stratified screening using serum biomarkers, and the appropriate integration of advanced endoscopic technologies.
These APGCC consensus recommendations provide practical guidance for improving the early detection of NCGC in low- to moderate-prevalence regions. This consensus also highlights important evidence gaps and establishes a framework for future research and the development of region-specific GC screening strategies.

PMID:
42873462
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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