Exogenous nitric oxide as an anti-infective agent.

Authors

Carl F Nathan

Published in

The Journal of experimental medicine. Volume 223. Issue 12. Dec 07, 2026. Epub Oct 14, 2026.

Abstract

Both before and after the discovery that the high-output isoform of nitric oxide (NO) synthase (iNOS; NOS2) contributes to control of many infectious diseases, investigators have been treating infections with exogenous NO or NO-related moieties. Here, we review the anti-infective potential of topically applied NO-releasing materials, systemically administered anti-infective drugs that generate NO-related moieties, and inhalation of NO gas. Evidence for the safety and efficacy of inhaled NO (iNO) at higher doses than typically used in cardiopulmonary medicine encouraged us to discuss prospects for iNO to help treat pulmonary infections, with a focus on tuberculosis.

PMID:
42873802
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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