Authors
Mingze Wu, Juan Hua, Yao Zhou, Yu Zhang, Lin Zhang, Yu Wang, Qinmei Xiong
Published in
Clinical cardiology. Volume 49. Issue 10. Pages e70494.
Abstract
Perturbations in iron homeostasis can substantially affect cardiovascular outcomes. This study aims to evaluate the prognostic value of various iron homeostasis indicators for all-cause mortality in critically ill AF patients.
Data for this retrospective study were obtained from the Medical Information Mart for Intensive Care IV database. Based on the iron homeostasis-related indicators (ferritin, serum iron, transferrin, and total iron-binding capacity [TIBC]), the risks of 1-year mortality among critically ill patients with atrial fibrillation were calculated using Cox proportional-hazards regression. Associations of iron homeostasis indicators with all-cause mortality in critically ill AF patients were assessed via Kaplan-Meier curves, restricted cubic splines, and subgroup analyses.
After multivariable adjustment, patients in the highest ferritin quartile had a greater risk of 1-year mortality than those in the lowest quartile (Q4 HR 1.277, 95% CI 1.083-1.506, p < 0.01). In contrast, the highest quartiles of transferrin (Q4 HR 0.732, 95% CI 0.622-0.861, p < 0.01) and TIBC (Q4 HR 0.732, 95% CI 0.622-0.861, p < 0.01) were associated with lower mortality. No significant association was observed between serum iron quartiles and 1-year mortality (Q4 HR 1.067, 95% CI 0.914-1.245, p = 0.41). Restricted cubic spline analyses further characterized the exposure and outcome patterns for these iron-related parameters.
Among critically ill patients with AF, ferritin, transferrin and TIBC levels were independently associated with 1-year all-cause mortality. No significant association was observed for serum iron.
PMID:
42872906
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.
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