Authors
Lida Aeindartehran, Luke Kwan, Ibrahim Tahir, Daniel K Unruh, Maria Petrov, William B Stoll, Alejandro Alvarez, Jia-Sen Hu, Ejaz Ahmed, Nilanjan Seal, Nathan Taton, Anja Milenkova, Robert E Dinnebier, Murillo Longo Martins, Yongqiang Cheng, Anibal J Ramirez-Cuesta, Jin S Zhang, Michael T Ruggiero, Panče Naumov, Tomče Runčevski
Published in
Proceedings of the National Academy of Sciences of the United States of America. Volume 123. Issue 42. Pages e2608878123. Oct 20, 2026. Epub Oct 14, 2026.
Abstract
While fivefold point symmetry is common in nature, fivefold spatial symmetry is seldom observed. Regular pentagons cannot tile a plane without leaving voids, and even the densest "ice-ray" packing is exceptionally rare. Fivefold helices are equally elusive. We report a small molecule that self-assembles into hydrogen-bonded pseudo-fivefold helices and adopts an ice-ray pentagonal packing motif over crystallographic length scales using peripheral disorder that partially occupies regions that would otherwise be void in an ideal pentagonal tessellation. The resulting structure exhibits weak and nondirectional interhelical interactions within the (bc) plane and comparatively strong and directional intrahelical hydrogen bonding along the a axis. This structural anisotropy gives rise to single crystals with large aspect ratios and distinct mechanical behavior. This realization of two rare structural motifs within a single crystal shows the capability of simple organic molecules to form complex structures and highlights an untapped potential for symmetry engineering in molecular solids through the interplay of intermolecular interactions with pronounced differences in strength and directionality.
PMID:
42873786
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.
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