Authors
Amir Ajoolabady, Rizwan Ahmad, Glowi Alasiri, Mohammed Alaidarous, Randa Mohammad Ibrahim, Bonglee Kim, Altaf A Abdulkhaliq, Anwar Borai, Jaakko Tuomilehto, Bahauddeen M Alrfaei, Jun Ren, Johra Khan, Domenico Pratico
Published in
Molecular neurobiology. Volume 63. Issue 1. Sep 03, 2026. Epub Sep 03, 2026.
Abstract
HMGB1 (high mobility group box 1 protein) refers to a chromatin-associated protein localized in the cytosol to be secreted to the extracellular milieu from multiple cell types including immune and non-immune cells. In this context, HMGB1 functions as a proinflammatory cytokine. Microglia as the main resident immune cells in the brain actively express and secrete HMGB1. Accumulative evidence suggests that HMGB1, released not only by microglia but also astrocytes and endothelial cells, plays a central role in mediating inflammatory signaling and driving the progression of neuroinflammation. In this review, we aim to discuss the critical role and key implications of HMGB1 in neuroinflammation, focusing on the most recent studies and discoveries in this area.
PMID:
42693355
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.
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