Disarming CH25H to clear α-synuclein.

Authors

Guangyu Wu, Qin Wang

Published in

Trends in molecular medicine. Oct 14, 2026. Epub Oct 14, 2026.

Abstract

α-Synuclein (α-Syn) accumulation is a defining feature of Parkinson's disease (PD). Zhang et al. identify cholesterol 25-hydroxylase (CH25H) as an astrocytic inhibitor of p62-dependent α-Syn degradation. Disrupting the CH25H-p62 interaction facilitates α-Syn clearance via autophagy and improves PD-like phenotypes, suggesting a previously unrecognized nonenzymatic function for CH25H with therapeutic potential.

PMID:
42875281
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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