Eosinophilic Gastroenteritis during Tocilizumab Treatment for Castleman Disease.

Authors

Hiromitsu Kaneko, Kenta Hayashino, Hiroki Kobayashi, Yuki Fujiwara, Takeru Aasano, Shoka Kimura, Machiko Hotta, Kenji Takashima, Yasushi Hiramatsu

Published in

Internal medicine (Tokyo, Japan). Volume 65. Issue 20. Pages 2750-2757. Epub Oct 15, 2026.

Abstract

Eosinophilic gastroenteritis (EGE) is a rare inflammatory disorder characterized by eosinophilic infiltration of the gastrointestinal tract and its associated symptoms. We report a case of EGE in a patient with idiopathic multicentric Castleman disease and asthma, who developed gastrointestinal symptoms and eosinophilia during tocilizumab therapy. Endoscopy revealed marked gastric mucosal injury and biopsy confirmed eosinophilic infiltration. Despite normal intestinal endoscopic findings, the biopsy specimens revealed eosinophilic infiltration. The discontinuation of tocilizumab and initiation of prednisolone resulted in complete symptom resolution, suggesting that the onset of EGE may have been associated with tocilizumab treatment.

PMID:
42875217
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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