Clinical Characteristics Associated with Mortality between Surviving and Non-surviving Adult Patients with Severe Influenza Requiring Hospitalization: An Internet-based, Prospective, Multicenter, Cohort Study in Japan.

Authors

Masafumi Seki, Akihiro Ito, Yuki Shiko, Maiko Osawa, Yukiko Oya, Kazuhiro Tateda, Jiro Fujita, Kosaku Komiya, Akihiko Kawana, Koichi Izumikawa, Toshiaki Kikuchi, Norio Ohmagari, Mitsuhiro Yamada, Takaya Maruyama, Takahiro Takazono, Makoto Miki, Yoshitsugu Miyazaki, Yoshitaka Yamazaki, Hiroshi Kakeya, Yuta Hayashi, Hideaki Nagai, Tadashi Ishida

Published in

Internal medicine (Tokyo, Japan). Oct 15, 2026. Epub Oct 15, 2026.

Abstract

Introduction　Influenza remains a huge issue, but its prognosis and clinical characteristics are still unclear. This study aimed to clarify the clinical differences between adults hospitalized with influenza between survivors and nonsurvivors.Methods　Clinical data of patients who were severely ill with influenza and required hospitalization were gathered and analyzed between September 2019 and August 2025 (six influenza seasons) using an internet surveillance system; patients who did not survive were excluded.Results　Of the 490 patients with severe influenza, 32 (6.53%) did not survive and were older than the surviving patients. In the non-surviving patients, very few or none had been vaccinated against influenza or pneumococcal infections. The non-surviving patients had more pure viral pneumonia and more received mechanical ventilation. The male-to-female ratio, underlying diseases, virus type, and use of antibiotics were similar between survivors and non-survivors.Conclusions　Non-surviving patients were older and developed more severe respiratory failure due to pure viral pneumonia than surviving patients. Very low vaccination rates for influenza and pneumococcus might be suggested in hospitalized adults with severe influenza.

PMID:
42875207
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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