Nintedanib-induced Glomerular Microangiopathy after Long-term Nintedanib Administration Presenting with Nephrotic Syndrome.

Authors

Mizuki Watada, Yurina Yataka, Motoki Hoshino, Wakana Shoda, Tamaki Kuyama, Kiyotaka Nagahama, Daiei Takahashi

Published in

Internal medicine (Tokyo, Japan). Volume 65. Issue 20. Pages 2715-2719. Epub Oct 15, 2026.

Abstract

We herein report a rare case of nintedanib-induced glomerular microangiopathy (GMA) in a 77-year-old woman with idiopathic pulmonary fibrosis. The patient developed nephrotic-range proteinuria (5.9 g/gCr) after 29 months of nintedanib therapy. A kidney biopsy confirmed GMA, which was characterized by endothelial injury without immune complex deposition. The discontinuation of nintedanib led to a significant reduction in proteinuria. This case demonstrates that nintedanib-induced GMA can manifest after long-term use. Given the potential for a global underdiagnosis, regular urinalysis testing is therefore essential for the early detection of irreversible renal damage, particularly in elderly patients.

PMID:
42875216
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.

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