Authors
Shuxin Song, Satoshi Hirayama, Haruka Inaba, Atsushi Hori, Yuna Horiuchi, Yuri Ichikawa, Yutaka Kimura, Yoshifumi Fukushima, Tsuyoshi Ueno, Yuki Uehara, Takashi Miida
Published in
Journal of atherosclerosis and thrombosis. Oct 14, 2026. Epub Oct 14, 2026.
Abstract
Lipoprotein(a) (Lp(a)) is a strong risk factor for cardiovascular events, independent of low-density lipoprotein cholesterol (LDL-C). Because the Lp(a) concentration is largely determined by genetic factors, some dyslipidemia guidelines recommend a once-in-a-lifetime measurement of Lp(a). Furthermore, a non-fasting lipid profile assessment is allowed for initial screening of dyslipidemia. Although the LDL-C concentration decreases slightly throughout the day, the within-day variation of Lp(a) remains unknown. We aimed to investigate whether the Lp(a) concentration remains stable throughout the day.
Lp(a) concentrations were measured at seven time points throughout the day in 34 patients using a latex turbidimetric immunoassay. The Lp(a) values are expressed in molar units, which are equivalent to those determined by a mass spectrometry-based reference measurement procedure.
We found that the Lp(a) concentrations decreased by 2.9±5.2 nmol/L at 14:00 (p＜0.05), 3.6±4.8 nmol/L at 20:00 (p＜0.001), and 2.9±5.1 nmol/L at 24:00 (p＜0.05). The mean percent Lp(a) decreased significantly at 17:30 (-6.2±0.1%) and 24:00 (-7.0±0.1%) from the fasting level.
The Lp(a) concentration decreases slightly, but significantly, throughout the day. Considering physiological variations, it is preferable to re-evaluate the Lp(a) concentration in those with a borderline elevation.
PMID:
42875228
Bibliographic data and abstract were imported from PubMed on 15 Oct 2026.
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